RAF Typhoon FGR4s have joined forces with France's air force in a combined operation on an hidden munitions depot in Syrian territory operated by the IS group, according to the British defence ministry.
The location, pinpointed through reconnaissance, was assessed as containing munitions and bombs, the statement said, and was located in mountains just above Palmyra in central Syria.
"The RAF jets utilized Paveway IV guided bombs to target a number of access tunnels providing entry to the facility... initial indications suggest the objective was successfully hit," the ministry announced.
There was no sign of any civilian impact in the attack late on Saturday and each participating jet made a safe return, the defence officials confirmed.
The British jets were supported by a Voyager aerial refuelling aircraft.
IS - also known as the so-called Islamic State - enforced jihadist rule over large swathes of Iraq and Syria until 2019.
"This action demonstrates the UK's leading role, and resolve to stand shoulder to shoulder with allied nations, to eliminate any resurgence of Daesh and their harmful and extremist ideologies in the Middle East," Britain's Defence Chief the minister remarked.
RAF aircraft have conducted overwatch operations over Syria to "deter any attempted resurgence" of IS subsequent to its defeat at the battle of Baghuz in 2019, the MoD reported.
"I extend gratitude to every member of British forces who took part in this mission for their professionalism and their bravery," he commented. "Including them were numerous British troops stationed over the holidays. This operation, to eliminate terrorist threats who pose a risk to our safety, highlights how our armed forces are prepared to act, all year round, ensuring Britain's security domestically and powerful internationally."
During December, the US military executed what it described as a "massive strike" targeting Islamic State objectives in the country, following an ambush claimed the lives of two US servicemembers and a local interpreter in Palmyra.
The United Nations reports Daesh still boasts between 5,000 and 7,000 militants in both countries.